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IMS 2024 | Updates on the QUINTESSENTIAL trial: second-generation anti-GPRC5D CAR-T in myeloma
Susan Bal, MD, University of Alabama at Birmingham, Birmingham, AL, briefly discusses the QUINTESSENTIAL trial (NCT06297226), which evaluates BMS-986393, a second-generation autologous anti-GPRC5D CAR T-cell therapy, in patients with multiple myeloma (MM). Phase I results showed an encouraging response rate of 91% at the recommended Phase II dose, with fewer off-target toxicities compared to other GPRC5D therapies, and the study is now progressing to a larger Phase II trial. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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