Constantine Tam, MBBS (Hons), MD, FRACP, FRCPA, of The Peter MacCallum Cancer Centre, Melbourne, Australia, outlines the phase III study (NCT04002297) comparing the efficacy of zanubrutinib, a BTK inhibitor, with rituximab against standard treatment in first-line mantle-cell lymphoma patients. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).