Stefano Casola, MD, FIRC Institute of Molecular Oncology, Milan, Italy, elaborates on the role of, and interference with, immunoglobulin receptors in chronic lymphocytic leukemia (CLL), while also discussing the ability to predict resistant tumor cells. This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.