Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, gives an update on the DEFIFrance study (NCT02851407) investigating defibrotide in patients with hepatic veno-occlusive disease (VOD) in the real-world. Overall, the study confirmed the efficacy of defibrotide for the treatment of severe VOD and showed that safety profile of this drug was similar to what was observed in clinical trials. In addition, it highlighted the importance of rapid intervention to improve the outcomes of patients suffering from this severe complication. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.