Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, discusses donor selection for allogeneic stem cell transplantation (alloSCT) and compares matched related versus unrelated versus haploidentical donors. Prof. Mohty first comments on the challenges associated with donor selection and then explains the importance of immune intervention and post-transplant maintenance in ensuring long-term, durable responses. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.