Key scientific principles that hematology nurses need to be aware of to manage patients receiving CAR T-cell therapy are discussed here by Kathleen McDermott, RN, BSN, OCN, BMTCN, of the Dana-Farber Cancer Institute, Boston, MA. She highlights the need for nurse education on various aspects of CAR T-cell therapy, such as toxicity knowledge and management, CRP measurement, and awareness of toxicity grading. This interview took place at the UK Oncology Nursing Society (UKONS) 2018 Annual Conference, in Glasgow, UK.