Despina Fotiou, MD, PhD, University of Athens, Athens, Greece, discusses the prognostic impact of t(11;14) in patients with newly diagnosed AL amyloidosis. Dr Fotiou first explains how t(11;14) may decrease patient response to treatment with bortezomib, and then highlights the potential role of BCL2 inhibitors in these patients. This interview took place at the 2022 International Symposium on Amyloidosis (ISA) held in Heidelberg, Germany.