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ASH 2022 | Results from the Phase I SAL-RELAX trial: venetoclax plus cytarabine and mitoxantrone in R/R AML

Christoph Röllig, MD, MSc, Dresden University of Technology, Dresden, Germany, outlines the results of the Phase I SAL-RELAX trial (NCT04330820), which investigated whether combining standard cytoreductive high-dose cytarabine and mitoxantrone with the BCL2 inhibitor venetoclax could increase response to salvage in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML). Results demonstrated that it is safe and feasible to combine these agents, with a high response rate observed. This interview took place at the 64th ASH Annual Meeting and Exposition congress held in New Orleans, LA.

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BMS: Consultancy, Honoraria; Amgen: Honoraria; AbbVie: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Honoraria; Novartis: Consultancy, Honoraria, Research Funding; Servier: Consultancy; Jazz: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria, Research Funding; Roche: Consultancy, Honoraria.

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