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COSTEM 2022 | Is it possible to efficiently prevent GvHD with a modified PTCy dosing schedule?

Christopher Kanakry, MD, National Cancer Institute, Bethesda, MD, describes the history behind the dosing schedule of post-transplant cyclophosphamide (PTCy) in haploidentical transplantation and explains the results of a recent study evaluating the feasibility of a lower dosing schedule of PTCy to prevent the incidence of graft-versus-host disease (GvHD). Overall, the study showed that using half of the standard PTCy dose on day 4 or on days 3 and 4 post-transplant led to effective GvHD prevention, better immune reconstitution, and lower transplant-related toxicity. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.

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