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EHA 2024 | An investigation into vaccinating against mutated RAS in multiple myeloma

RAS mutations are the most common genetic aberrations observed in multiple myeloma (MM). In this video, Hanne Norseth, MD, Oslo University Hospital, Oslo, Norway, introduces the Phase I TG01 study (NCT05841550), which assesses the use of vaccination against mutated RAS in patients with myeloma. Patients enrolled in the trial have either high-risk smoldering myeloma (HR-SMM) or stable/indolent disease, meaning the effect of the vaccine can be studied. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

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Disclosures

Honoria: Janssen, BM; Advisory board: Sanofi; Researh funding: Circio.