Sasanka Handunnetti, MBBS, FRACP, FRCPA, Peter MacCallum Cancer Centre, Melbourne, Australia, outlines the rationale and results of the AIM trial (NCT02471391), investigating the combination of ibrutinib and venetoclax in relapsed/refractory mantle cell lymphoma (MCL). Results from this three-year update are promising and demonstrate that ibrutinib in combination with venetoclax offers durable responses to patients who otherwise have limited durable therapeutic options. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.