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ASH 2022 | Investigating the safety & efficacy of magrolimab, azacitidine & venetoclax in patients with AML

Naval Daver, MD, University of Texas MD Anderson Cancer Center, Houston, TX, outlines findings from a Phase I/IIb study investigating the efficacy and safety of magrolimab, azacitidine and venetoclax in patients with acute myeloid leukemia (AML). Overall, the three-drug combination was well-tolerated and elicited minimal myelosuppression, with patients also achieving a higher overall survival (OS) than with standard treatment. With many patients in this study harboring a TP53 mutation, Dr Daver believes that this novel combination could be considered in the frontline setting in the future, however, further investigation is required to fully understand the impact of TP53 mutation on the efficacy of this regimen. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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Disclosures

Agios, Celgene, SOBI and STAR Therapeutics: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Kartos and Jazz Pharmaceuticals: Other: Data monitoring committee member; Karyopham Therapeutics and Newave Pharmaceutical: Research Funding; Astellas, AbbVie, Genentech, Daiichi-Sankyo, Novartis, Jazz, Amgen, Servier, Karyopharm, Trovagene, Trillium, Syndax, Gilead, Pfizer, Bristol Myers Squibb, Kite, Actinium, Arog, Immunogen, Arcellx, and Shattuck: Consultancy, Other: Advisory Role; Astellas, AbbVie, Genentech, Daiichi-Sankyo, Gilead, Immunogen, Pfizer, Bristol Myers Squibb, Trovagene, Servier, Novimmune, Incyte, Hanmi, Fate, Amgen, Kite, Novartis, Astex, KAHR, Shattuck, Sobi, Glycomimetics, Trillium: Research Funding.