Enrico Attardi, MD, University of Rome Tor Vergata, Rome Italy, discusses the clinical implications related to the identification of inherited predisposition to myeloid malignancies such as myelodysplastic syndromes (MDS). Knowledge of these germline variants can be used for genetic counseling, but also to help understand the biology of the disease, and to personalize treatment. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.