ASH 2023 | Variant allele frequency in patients with SF3B1-mutated MDS
Curtis Lachowiez, MD, Oregon Health & Science University, Portland, OR, presents research investigating the significance of variant allele frequency (VAF) in patients with SF3B1-mutated myelodysplastic neoplasms (MDS). Patients with SF3B1 VAF of lower than 10% exhibited more adverse disease biology and increased co-mutation frequency compared to those with VAF of ≥ 10%, indicating SF3B1 mutations as the primary genomic driver in high VAF cases, while likely sub-clonal in low VAF cases. Despite this distinction, there were no significant differences in leukemia-free survival (LFS) and overall survival (OS) between the two cohorts. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Rigel, AbbVie, Servier, COTA Healthcare.
