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iwCLL 2023 | PROTACs: potential novel agents for the treatment of CLL

In this video, Deepa Sampath, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, introduces proteolysis targeting chimeras (PROTACs) and outlines how these agents have been investigated in chronic lymphocytic leukemia (CLL) cells, in which they target BCL2 and Bcl-xL (PROTACs PZ18753b and WH25244). Dr Sampath hopes to introduce these agents to the clinic by 2024, as they are effective in both venetoclax-sensitive and venetoclax-resistant CLL. This interview was recorded at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA.

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