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ASCO 2023 | ASC2ESCALATE: Phase II dose-escalation study of second-line asciminib in patients with CML-CP

Jorge Cortes, MD, Augusta University, Augusta, GA, describes the rationale and aims of the Phase II ASC2ESCALATE study (NCT05384587) evaluating the safety and efficacy of asciminib in the second-line setting with dose-escalation in patients with chronic myeloid leukemia in chronic phase (CMP-CP) who do not achieve BCR:ABL1IS ≤ 1% at 6 months.

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Disclosures

Consultant for Pfizer, Novartis, Takeda, Sun Pharma, Rigel and Forma Therapeutics. Dr Cortes’ institution receives research support from Pfizer, Takeda, Novartis and Sun Pharma.