Jorge Cortes, MD, Augusta University, Augusta, GA, describes the rationale and aims of the Phase II ASC2ESCALATE study (NCT05384587) evaluating the safety and efficacy of asciminib in the second-line setting with dose-escalation in patients with chronic myeloid leukemia in chronic phase (CMP-CP) who do not achieve BCR:ABL1IS ≤ 1% at 6 months.
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