Hagop Kantarjian, MD, University of Texas MD Anderson Cancer Center, Houston, TX, outlines the recent advancements in leukemia treatment that have transformed patient outcomes. The use of BCR-ABL tyrosine kinase inhibitors has revolutionized chronic myeloid leukemia treatment paradigm, as has ibrutinib plus venetoclax combination therapy in chronic lymphocytic leukemia. Combining chemotherapy with targeted agents has proved an effective approach in acute myeloid leukemia and acute lymphoblastic leukemia where response rates and survival are better than ever before. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.