Rafael Bejar, MD, PhD, University of California San Diego, San Diego, CA, shares some insights into the role of clonal hematopoiesis of indeterminate potential (CHIP) in the development of myeloproliferative neoplasms (MPNs), and the importance of better understanding precursor conditions to prevent disease progression. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.