Stephan Stilgenbauer, MD, University of Ulm, Ulm, Germany, discusses the final results from the phase IIIb GREEN study (NCT01905943) of obinutuzumab alone or combined with chemotherapy in previously untreated or relapsed/refractory chronic lymphocytic leukemia (CLL) . Efficacy outcomes suggest a favorable benefit/risk profile and no new safety signals were identified. Prof. Stilgenbauer reveals that in IGHV-mutated patients and in the absence of high-risk genomic features there is still a role for chemoimmunotherapy. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.