Akshay Sharma, MBBS, St. Jude Children’s Research Hospital, Memphis, TN, presents a case study of the use of daratumumab, an anti-CD38 monoclonal antibody, for post-transplant autoimmune-like hepatitis in a patient with B-cell acute lymphoblastic leukemia who underwent hematopoietic cell transplantation. This interview took place during the Transplantation & Cellular Therapy (TCT) 2021 Meetings.