Sigurdur Sigurdsson, of the Icelandic Heart Association, Kopavogur, Iceland, discusses the issue of distinguishing sepsis and cytokine release syndrome (CRS) in patients treated with CAR-T therapy. He highlightsthe importance of treatment with antibiotics in case of sepsis. This interview took place at the CAR-T Cell Therapy and the ICU 2019 meeting in London, UK, which was organized by EuroCARTForce.