Moshe Mittelman, MD, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, discusses the latest progress in the myelodysplastic syndromes (MDS) field. Specifically, he focuses on identifying targets for novel treatments and progress in digitalized medicine to allow for a more personalized approach. This interview took place at the 2nd Regional Symposium on Myelodysplastic Syndromes (MDS 2020), held in Tel Aviv, Israel.