Kerry Rogers, MD, The Ohio State University, Columbus, OH, discusses highlights in the field of chronic lymphocytic leukemia (CLL) from ASH 2020, including the Phase III Unity-CLL study (NCT02612311) comparing umbralisib plus ublituximab to obinutuzumab plus chlorambucil in patients with treatment naïve and relapsed/refractory CLL, and the Phase I/II BRUIN study (NCT03740529) investigating the Bruton’s tyrosine kinase inhibitor LOXO-305 in CLL/small lymphocytic leukemia. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.