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IWWM-11 2022 | Changes in gene expression in patients with WM after treatment with BTK inhibitors

Amy Christian, BSc, MSc, University Hospitals Dorset NHS Foundation Trust, Dorset, UK, discusses the results from a pilot study which used next-generation sequencing (NGS) techniques to evaluate changes in gene expression in patients with Waldenström’s macroglobulinemia (WM) before and after treatment with a Bruton’s tyrosine kinase (BTK) inhibitor. Ms Christian notes the upregulation of NCR1 and downregulation of CXCL13 observed in patients treated with acalabrutinib. This interview took place at the 11th International Workshop on Waldenström’s Macroglobulinemia (IWWM-11), held in Madrid, Spain.

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