David Sallman, MD, Moffitt Cancer Center, Tampa, FL, discusses PRGN-3006, a novel chimeric antigen receptor T-cell (CAR-T) therapy, in the treatment of patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Dr Sallman highlights the mechanism of action of this CAR, its manufacturing process, and concludes by discussing the safety of this product and promising response rates observed in patients. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA, 2021.