ESH AL 2024 | The impact of clonal hematopoiesis on outcomes of ALL
Caner Saygin, MD, University of Chicago, Chicago, IL, discusses a study investigating the role of myeloid mutations in therapy-related acute lymphoblastic leukemia (ALL). This study found that patients with TP53 mutations and clonal hematopoiesis of indeterminate potential (CHIP) had inferior outcomes compared to those without. Single-cell proteogenomic analysis indicated that these myeloid mutations were present years before ALL onset, underscoring the importance of tracking clonal hematopoiesis in high-risk patients and considering treatments to prevent progression. This interview took place at the 4th European School of Hematology Acute Leukemia (ESH AL) congress in Stockholm, Sweden.
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