Claire Dearden, MBBS, MD, FRCP, FRCPath from the Royal Marsden Hospital, London, UK, discusses familial risk in CLL at the 2017 British Society for Haematology (BSH) Annual Scientific Meeting in Brighton, UK. Currently, there are 20 known genes involved B cell development, that if inherited, increase susceptibility to CLL. This research is not at a point where these genes can be used to predict CLL. These genes, however, are used as risk factors. Individuals who have a family member with CLL are 8 times more likely to develop the disease themselves. This video has been supported by Napp Pharmaceuticals Ltd through an unrestricted educational grant to Magdalen Medical Publishing.