Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, gives an overview of a retrospective study investigating the occurrence of other malignancies in other patients with chronic lymphocytic leukemia (CLL). Dr Scarfò reports that chemoimmunotherapy increases the risk of acute myeloid leukemia and myelodysplasia, in particular with the combination of fludarabine, cyclophosphamide and rituximab. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.