Petri Pölönen, PhD, St. Jude’s Research Hospital, Memphis, TN, discusses the results of a study which used whole genome sequencing (WGS), whole exome sequencing (WES), and transcriptome sequencing to characterize the genome of pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL). Dr Pölönen highlights novel T-ALL driver genes and genomic alterations that were identified. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.