In this video, David Sallman, MD, Moffitt Cancer Center, Tampa, FL, briefly highlights the response of patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) to the COVID-19 vaccine. Dr Sallman mentions the need to obtain more data in the future on survival and risk of hospitalization, and emphasizes the importance of current data, which strongly supports vaccination in patients with hematological malignancies. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA, 2021.