iwCLL 2023 | STELLAR: genomic sequencing of ctDNA reveals additional driver mutations in Richter’s transformation
Anna Schuh, MD, PhD, University of Oxford, Oxford, UK, outlines ongoing research as part of the ongoing STELLAR trial (NCT03899337) which aims to compare R-CHOP with or without acalabrutinib in patients with newly diagnosed Richter’s transformation (RT). Genomic analysis of tumor tissue and circulating tumor DNA (ctDNA) have revealed a difference in the number of mutations between samples, with additional driver mutations (such as TP53) being identified in ctDNA. This interview took place at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2023 meeting, held in Boston, MA.
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