ASH 2023 | Does acalabrutinib increase the risk of hypertension in patients with CLL?
Alessandra Ferrajoli, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses an analysis comparing the rate of new or worsening hypertension in patients with chronic lymphocytic leukemia (CLL) who were treated with acalabrutinib to real-world prevalence and incidence of hypertension in patients with CLL prior to treatment initiation. Although prior studies have shown increased rates of new or worsening hypertension when treating CLL with other BTK inhibitors (ibrutinib and zanubrutinib), this analysis determined that acalabrutinib monotherapy did not worsen pre-existing hypertension or increase the risk of new-onset hypertension. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Honoraria: Genetech, Janssen, AstraZeneca, Abbvie
Research Funding: GenMab, Beigene, AstraZeneca, Abbvie
