ASH 2025 | Results of a survey investigating fertility and outcomes after CAR T-cell therapy
Florent Malard, MD, PhD, Saint-Antoine Hospital and Sorbonne University, Paris, France, comments on the results of a survey assessing fertility and outcomes after CAR T-cell therapy. Dr Malard notes that the survey found a significant number of reported pregnancies, mostly in women who did not require medical support, which is a promising outcome for young patients undergoing this treatment. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.
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Transcript
With the Cellular Therapy Immunobiology Working Party of the EBMT, with my colleague Giorgio Orofino, that is working in Italy, we conducted this survey to assess if we have some patients that manage to have some children after CAR T-cells. And we performed this survey within the EBMT Center, and we were surprised to see that, in fact, we have a lot of pregnancies that were reported, and that in the majority of them, it was some women that were able to achieve some pregnancies which had any medical support for the pregnancy...
With the Cellular Therapy Immunobiology Working Party of the EBMT, with my colleague Giorgio Orofino, that is working in Italy, we conducted this survey to assess if we have some patients that manage to have some children after CAR T-cells. And we performed this survey within the EBMT Center, and we were surprised to see that, in fact, we have a lot of pregnancies that were reported, and that in the majority of them, it was some women that were able to achieve some pregnancies which had any medical support for the pregnancy. So this is some very good results. We need to dig more in details and also to look if we have also some women that tried to have some children and did not manage to have them. But I think this is good to have this kind of study because it’s also some hope for the young women, but also for the young men that received this kind of treatment to say that there is a life after the disease, that we are going to cure them. But it’s not only to cure them, but also that they can have a normal life and a family.
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