The results of a phase 1 trial (NCT03709758) of escalating doses of venetoclax with daunorubicin/cytarabine (7+3) induction and high dose cytarabine consolidation in untreated adults acute myeloid leukemia (AML) were presented at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL. Here Daniel DeAngelo, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, discusses the preliminary results, which show promise.