Elias Jabbour, MD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses the feasibility of modifying the dose of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) to decrease the incidence of vascular events, highlighting data from the PACE (NCT01207440) and OPTIC (NCT02467270) trials. Overall, it was shown that adjusting drug dose based on response optimized treatment safety without compromising efficacy. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.
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