Jean-Jacques Kiladjian, MD, PhD, Saint-Louis Hospital, University of Paris, Paris, France, highlights the exciting new genomic findings in myeloproliferative neoplasms (MPN) presented at ASH 2020, focusing on the genetic mutations that may drive MPN progression and targets for MPN therapy. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.