Jean-Jacques Kiladjian, MD, PhD, Saint-Louis Hospital & Paris Diderot University, Paris, France, discusses the results from the long-term use of ropeginterferon alpha-2b (ropeg) in polycythemia vera (PV). Data shows ropeg minimizes the occurrence of thromboembolic events and is capable of inducing deep molecular responses, unlike hydroxyurea. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.