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EHA 2024 | Novel quadruplet and triplet front-line options for early R/R multiple myeloma

Saad Usmani, MD, MBA, FACP, Memorial Sloan Kettering Cancer Center, New York, NY, discusses how novel triplet and quadruplet regimens have transformed front-line treatment for early relapsed/refractory (R/R) multiple myeloma (MM). The BENEFIT (NCT04751877) and IMROZ (NCT03319667) trials support using these regimens even in elderly patients. Dr Usmani also notes the need to consider the efficacy of regimens incorporating anti-CD38 antibodies in patients previously exposed to these agents. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

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Disclosures

Research funding: Abbvie, Amgen, Array Biopharma, BMS, Celgene, GSK, Janssen, Merck, Pharmacyclics, Sanofi, Seattle Genetics, SkylineDX, Takeda. Consulting: Abbvie, Amgen, BMS, Celgene, EdoPharma, Genentech, Gilead, GSK, Gracell Therapeutics, Janssen, Oncopeptides, Sanofi, Seattle Genetics, SecuraBio, SkylineDX, Takeda, TeneoBio.