Leonardo Brandão, MD, MSc, The Hospital for Sick Children, University of Toronto, Toronto, Canada, gives an overview on the treatment and management of severe congenital protein C deficiency (SCPCD), and the importance of raising awareness and improving treatment approaches for patients with this rare disease. This interview took place at the 30th Congress of the International Society on Thrombosis and Haemostasis (ISTH) 2022 held in London, UK.