Charles Craddock, CBE, FRCP (UK), FRCPath, DPhil, University of Birmingham, Birmingham, UK, highlights the key updates in the transplantation field from the at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL. Prof. Craddock specifically discusses the use of GvHD prophylaxis, the challenge of maximizing safety and how the risk of relapse can be reduced.