Here, Torsten Haferlach, MD, from the Munich Leukemia Laboratory, Munich, Germany, discusses how discrimination between types of myeloproliferative neoplasms (MPNs) can be achieved with genomic analysis using techniques such as next-generation sequencing (NGS), rather than relying solely on histological analysis. Prof. Haferlach was speaking at the 24th Congress of the European Hematology Association (EHA) 2019, held in Amsterdam, Netherlands.