Andrew Wei, MBBS, PhD, Alfred Hospital and Monash University, Melbourne, Australia, discusses the findings of a subgroup analysis of a Phase I trial (NCT03066648) investigating sabatolimab, a novel TIM-3 inhibitor, plus hypomethylating agents (HMAs) for patients with high-risk or very high-risk (HR/vHR) myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). Prof Wei discusses the mechanism of action of sabatolimab and highlights key findings from the study. 23% of patients who received sabatolimab plus HMAs were able to undergo allogeneic stem cell transplantation, with no evidence of treatment-related complications. Prof. Wei reports that the combination was well-tolerated and demonstrated an overall response rate of 58% in patients with HR-MDS. Prof. Wei also discusses the impact of molecular features such as TP53 on efficacy. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.