ASH 2022 | Phase I trial investigating CD8-depleted HLA-mismatched unrelated DLI in patients with MDS and AML
Hany Elmariah, MD, MS, Moffitt Cancer Center, Tampa, FL, describes the structure and findings of a study that examined the use of induction chemotherapy and CD8-depleted HLA-mismatched unrelated donor lymphocyte infusion (DLI) in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Results demonstrated that this novel cellular therapy approach was well tolerated, with no dose-limiting toxicities observed. Dr Elmariah highlights that future studies with larger patient cohorts are needed to confirm these observations and further evaluate the efficacy of this approach. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
Bristol Myers Squibb: Research Funding.
