Dharminder Chauhan, JD, PhD, of the Dana-Farber Cancer Institute, Boston, MA, explains how targeting bone marrow accessory cells in the tumor microenvironment, such as plasmacytoid dendritic cells (pDCs) which are in excess within multiple myeloma, could be used to increase responsiveness of the tumor cells to conventional and novel immune therapies. This interview was recorded at the International Myeloma Workshop (IMW) 2019, in Boston, MA.