Prithviraj Bose, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, offers his highlights from polycythemia vera (PV) data presented at ASH 2020. PTG-300, a hepcidin mimetic that acts by preventing iron release in erythropoiesis, represents a promising means for eliminating the need for phlebotomy in PV and improves the symptoms of iron deficiency. Dr Bose also discusses data from the 5-year update on ropeginterferon alpha-2b in PV patients, which showed sustained efficacy and a good toxicity profile. Additionally, he offers key takeaways from data presented on the observational REVEAL study (NCT02252159), which aims to provide real-world data on the clinical management of PV in the US. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.