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ASH 2025 | WGS of cfDNA for assessment of MRD in high-risk smoldering multiple myeloma

Chrissy Baker, MSc, PhD(c), University of Miami Miller School of Medicine, Miami, FL, discusses the potential of plasma-based cell-free DNA (cfDNA) analysis to assess measurable residual disease (MRD) in high-risk smoldering multiple myeloma (SMM). She explains how whole genome sequencing (WGS) of blood samples can capture disease heterogeneity, predict clinical outcomes, identify genomic drivers, and track disease progression, offering a less invasive alternative to bone marrow biopsies. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.

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