Duane Schulthess, BA, from Vital Transformation, Flanders, Belgium, discusses the necessity of real-world data for demonstrating the value of CAR T-cell therapy to health technology assessors. Speaking at the 1st European CAR T-Cell Meeting, held in Paris, France, Mr Schulthess reports that to overcome the barriers across both the approval process and reimbursement, it is crucial to prove the real-world safety, efficacy and cost-effectiveness of CAR T-cell therapy. This meeting was co-organized by the European Society for Blood & Marrow Transplantation (EBMT) and the European Hematology Association (EHA).