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IWWM-11 2022 | Tumor-associated CD66b+ MDSCs in WM and their impact on T-cell immune function

Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, discusses the role of myeloid-derived suppressor cells (MDSCs) in Waldenström’s macroglobulinemia (WM), and their impact on patient immune response. Prof. Ansell further explains the increase in MDSCs seen in the bone marrow of patients with WM, and the possibility of using these as a therapeutic target. This interview took place at the 11th International Workshop on Waldenström’s Macroglobulinemia (IWWM-11), held in Madrid, Spain.

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Research funding from Seattle Genetics, BMS, Affimed, Regeneron, Takeda, AstraZeneca, Pfizer, ADC Therapeutics to my institution for clinical trials.

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