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ASH 2024 | Racial differences in the proportion of myeloma cases attributable to obesity
Urvi Shah, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, comments on an analysis assessing the racial disparities in multiple myeloma (MM) cases attributable to modifiable risk factors, specifically obesity. Dr Shah notes that 10-19% of newly diagnosed myeloma cases are likely attributable to obesity, with a slight increase in risk observed in non-Hispanic black patients compared to non-Hispanic white patients. This suggests that while obesity is a significant risk factor, other factors may also contribute to the higher incidence of myeloma in black populations. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Transcript (AI-generated)
So we wanted to estimate the population attributable fraction or the number of cases of newly diagnosed myeloma that could be attributable to obesity as a risk factor, given this is a known risk factor, and how this may differentiate or be different in different races. What we did see or find is that 10 to 19% of myeloma cases that are newly diagnosed are likely attributable to obesity as a risk factor, suggesting that if there was no obesity, that 10 to 19% of cases could be reduced in terms of the risk of development...
So we wanted to estimate the population attributable fraction or the number of cases of newly diagnosed myeloma that could be attributable to obesity as a risk factor, given this is a known risk factor, and how this may differentiate or be different in different races. What we did see or find is that 10 to 19% of myeloma cases that are newly diagnosed are likely attributable to obesity as a risk factor, suggesting that if there was no obesity, that 10 to 19% of cases could be reduced in terms of the risk of development. And within that, we looked also at different racial groups, Hispanic, non-Hispanic black, and non-Hispanic white to see if there’s a difference in the proportion of these cases, given obesity is more frequent in non-Hispanic blacks and Hispanics compared to non-Hispanic whites. And what we see is that there is a slight increase in myeloma risk and incidence due to obesity in non-Hispanic blacks compared to non-Hispanic whites. That risk is not completely what estimates the total risk of the difference that is seen, so there may be other factors that also increase the risk in black compared to white populations, and obesity may be one of those causes.
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Disclosures
Sanofi: Honoraria; Bristol Myers Squibb: Research Funding; Janssen: Honoraria, Research Funding.
