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ASH 2022 | Zanubrutinib in acalabrutinib-intolerant patients with various B-cell malignancies

Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, shares the results of a trial which investigated the tolerability and efficacy of zanubrutinib in patients with B-cell malignancies who were intolerant to acalabrutinib. Overall, it was shown that zanubrutinib was well tolerated by the patient population, with majority of patients not experiencing the side effects that they experienced with acalabrutinib. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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Disclosures

MEI Pharma: Consultancy; Fate Therapeutics: Consultancy; Bristol Myers Squibb: Consultancy, Research Funding; TG Therapeutics: Consultancy, Research Funding; Innate Pharma: Consultancy; Epi Lilly: Consultancy; Adaptimmune: Consultancy; AstraZeneca: Consultancy, Research Funding; Epizyme: Consultancy; Mustang Bio: Consultancy, Research Funding; Beigene: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Regeneron: Consultancy; Merck: Consultancy; Adaptive Biotechnologies: Consultancy; Morphosys/Incyte: Consultancy, Research Funding; Pharmacyclics: Consultancy, Research Funding; Sound Biologics: Consultancy; Kite Pharma: Consultancy; Abbvie: Consultancy, Research Funding; Atara Biotherapeutic: Consultancy, Research Funding; Celgene, a BMS Company: Research Funding; Gilead: Research Funding; Sunesis: Research Funding; Genmab: Research Funding.